No relation to the London neighborhood of the same name, SoHo got its moniker as an abbreviation of "South of Houston Street" (pronounced HOUSE-ton). 

This super-fashionable neighborhood extends down to Canal Street, between Sixth Avenue to the west and Lafayette Street (1 block east of Broadway) to the east.
It's easily accessible by subway: Take the B, D, F, or Q train to the Broadway-Lafayette stop; the N, R to the Prince Street Station; or the C, E to Spring Street.
An industrial zone during the 19th century, SoHo retains the impressive cast-iron architecture of the era, and in many places, cobblestone peeks out from beneath the street's asphalt.
In the early 1960s, cutting-edge artists began occupying the drab and deteriorating buildings, soon turning it into the trendiest neighborhood in the city.
soho NYC
SoHo is now a prime example of urban gentrification and a major New York attraction thanks to its impeccably restored buildings, influential arts scene, fashionable restaurants, and stylish boutiques.
On weekends, the cobbled streets and narrow sidewalks are crowded with gallery-goers and shoppers, with the prime action being between Broadway and Sullivan Street north of Grand Street.
Some critics claim that SoHo is becoming a victim of its own popularity - witness the recent departure of several imaginative galleries and independent boutiques that fled to TriBeCa and Chelsea as well as the influx of suburban mall-style stores like J. Crew, Victoria's Secret, and Smith Hawken. However, SoHo is still one of the best shopping neighborhoods in the city, and few are more fun to browse.
High-end street peddlers set up along the boutique-lined sidewalks, hawking silver jewelry, coffee-table books, and their own art.
At night, the neighborhood is transformed into a terrific, albeit pricey, dining and bar-hopping neighborhood.
You can even stay here now, thanks to the introduction of two super-trendy hotels, the Mercer and the SoHo Grand. In recent years SoHo has been crawling its way east, taking over Mott and Mulberry streets and white-hot Elizabeth Street in particular - north of Kenmare Street, an area now known as NoLiTa for its North of Little Italy location. 
NoLiTa is becoming increasingly well known for its hot shopping prospects, which include a number of pricey antiques and home design stores.
Taking the 6 to Spring Street will get you closest by subway, but it's just a short walk east from SoHo proper.